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Fig. 7 | Journal of Translational Medicine

Fig. 7

From: Inhibition of endoplasmic-reticulum-stress-mediated autophagy enhances the effectiveness of chemotherapeutics on pancreatic cancer

Fig. 7

Anti-Ki67 immunohistochemistry showing differential reduction of cell proliferation in the pancreas of drug treated orthotopic murine model: The murine PDAC tissue from the control group shows significant proportion of Ki67 positive proliferating cells (arrow) in the pancreatic tissue. Although the Chemo alone does not reduce cell proliferation significantly (p = 0.16), the sunitinib treatment and all the combinatorial treatments significantly reduces the cell proliferation as shown in the bar-chart (p < 0.01). The triplet treatment with Chemo/Sun/CQ shows significantly reduced proliferation compared to the sham group (eightfold, p = 0.009), as well as further twofold lower from the doublet treatment groups (p < 0.01). *p < 0.05, **p < 0.01. Scale bar: 10 µm

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