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Fig. 6 | Journal of Translational Medicine

Fig. 6

From: Inhibition of endoplasmic-reticulum-stress-mediated autophagy enhances the effectiveness of chemotherapeutics on pancreatic cancer

Fig. 6

Anti-Grp78 immunohistochemistry showing differential expression of Grp78 in the pancreas of drug treated orthotopic murine model: Treatment with gemcitabine plus paclitaxel (Chemo) or Chemo + sunitinib increases the Grp78 levels in the ductal carcinoma (arrows) and surrounding cells (p < 0.05, Mann–Whitney U-test). This increased level of expression is reduced to basal level when Chemo was administered in combination with chloroquine, and sunitinib. While sunitinib alone also elevates Grp78 expression, a combination with Chloroquine reduces the elevated Grp78 to basal level. The intensity of Grp78 staining was ranked from 1 to 4 as weak, moderate, strong and very strong as shown in the bar-chart. *p < 0.05. Scale bar: 10 µm

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