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Fig. 1 | Journal of Translational Medicine

Fig. 1

From: Inhibition of endoplasmic-reticulum-stress-mediated autophagy enhances the effectiveness of chemotherapeutics on pancreatic cancer

Fig. 1

Anti-GRP78 immunostaining in PDAC tissue microarray and patient-derived pancreatic tissue biopsies. a Representative images of Anti-GRP78 immunohistochemistry (red chromogens) on PDAC tissue microarray showing different levels of GRP78 expression. PDAC tissues show consistently higher GRP78 expression (arrow) compared to non-tumor adjacent tissues (NAT). b Bar-charts showing increased level of GRP78 expression in PDAC tissues (p < 0.05, Mann–Whitney U-test). c IHC with anti-GRP78 antibody on biopsied pancreatic tissue samples from patients with a normal healthy pancreas, pancreatitis, and two separate cases of pancreatic tumors (PDAC-1 and PDAC-2). Enriched expression of GRP78 is evident in the invasive ductal adenocarcinoma cells (arrow) and the surrounding inflammatory stromal cells (arrowhead) in the tumor samples. GRP78 expression is also elevated in acini (arrow) and inflammatory cells (arrowhead) in pancreatitis, as compared to the minimal basal expression in healthy pancreas. Scale bar: 10 µm

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