Fig. 2

The expression of KLF4 in the nucleus was significantly correlated with H-Ras and PI3K mutations. IHC was used to detect the expression of c-Met protein. EGFR was expressed in the nucleus (nEGFR), and H-Ras mutation and PI3K mutation exerted a relatively poor effect on the prognosis in patients treated with cetuximab. A-a Low expression of c-Met in nasopharyngeal carcinoma. A-b Representative image of the high expression of c-Met in nasopharyngeal carcinoma tissues. A-c Representative imaged the low expression of nEGFR in the nucleus. A-d Representative image of high-expression of nEGFR in nasopharyngeal carcinoma. B-a Survival analysis showed that the expression of c-Met had a relatively poor effect on prognosis in cetuximab-treated nasopharyngeal carcinoma patients. B-b nEGFR expression had a relatively poor effect on prognosis; nasopharyngeal carcinoma patients with mutated H-Ras (B-c) and PI3K (B-d) mutations had a relatively poor prognosis after cetuximab treatment. C The cytoplasmic cKlf4 expression was not significantly correlated with the expression of c-Met, nEGFR, H-Ras, and PI3K mutations in nasopharyngeal carcinoma tissues, Nega short for negative and Posi short for positive. D The expression of KLF4 in the nucleus was significantly correlated with the expression of H-Ras and PI3K mutations