Fig. 1

KLF4 expressed in the nucleus had a relatively poor prognosis in patients treated with cetuximab. A Representative image of the IHC detection of KLF4 protein expression in nasopharyngeal carcinoma. A-a Low expression of KLF4 in the cytoplasm of nasopharyngeal carcinoma. A-c KLF4 was highly expressed in the cytoplasm. A-b Low expression of KLF4 in the nucleus of nasopharyngeal carcinoma cells. A-d KLF4 was highly expressed in the nucleus. B KLF4 in the survival analysis of nasopharyngeal carcinoma. B-a In nasopharyngeal carcinoma patients treated with cetuximab, the prognosis of patients with highly expressed cytoplasmic KLF4 was significantly better than that in those with low expression. B-d The nuclear expression of KLF4 had no significant effect on the prognosis in the patients without cetuximab treatment. B-c In the nasopharyngeal carcinoma patients treated with cetuximab, the expression of KLF4 in the cytoplasm had a better effect on the prognosis. B-d The expression of KLF4 in the nucleus had a relatively poor effect on the prognosis in the patients combine with cetuximab treatment