Fig. 3
A H/E malignant mesothelioma, epithelial type. B BAP1 immunostaining. Note absence of nuclear staining indicative of biallelic BAP1 inactivation and accumulation of truncated inactive BAP1 protein the the cytoplasm. Note nuclear staining in few inflammatory cells infiltrating among tumor cells, as these cells retain one wild-type BAP1 allele. Original magnification ×200