Association of the peripheral blood levels of circulating microRNAs with both recurrent miscarriage and the outcomes of embryo transfer in an in vitro fertilization process

Table 3 Receiver operating characteristic analysis in potential diagnostic biomarkers of RM in plasma

Roc index	Prediction for clinical pregnancy outcome
Roc index	Model 1^a (combination of the six miRNAs)	Model 2^b (combination of miR-127a-3p and miR-486-5p)
AuROC (95% CI)*	0.96 (0.92, 1.00)	0.90 (0.81, 0.99)
Sensitivity (%)	100	88.9
Specificity (%)	83.3	80.0
Positive predictive value (%)	78.3	72.7
Negative predictive value (%)	100	92.3
Correctly classified (%)	89.6	83.3
Cut-off value	0.213^a	0.336^b

* No significant difference in ROC area between Model 1 and Model 2
^aModel 1, Cut-off value = 0.213, (miR-23a-3p, miR-27a-3p, miR-29a-3p, miR-100-5p, miR-127a-3p, miR-486-5p) (6.312687, 6.228964, 13.70655, 13.10668, 9.521886, 4.800646)
^bModel 2, Cut-off value = 0.336, (miR-100-5p, miR-486-5p) (13.27899, 4.726676)

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