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Fig. 8 | Journal of Translational Medicine

Fig. 8

From: Polyethylene glycol-conjugated HER2-targeted peptides as a nuclear imaging probe for HER2-overexpressed gastric cancer detection in vivo

Fig. 8

a Tissue biodistribution of 111In-DTPA-AHNP-PEG in gastric tumor xenograft mice. After 111In-DTPA, 111In-DTPA-AHNP, 111In-DTPA-PEG, and 111In-DTPA-AHNP-PEG intravenous injection for 1, 4, 24, and 48 h, NCI-N87-induced xenograft mice were sacrificed and acquired tumor, blood, brain, heart, lung, liver, kidney, spleen, muscle, stomach, and colon. The radioactivity was determined by a gamma counter. Values are expressed as the percentage of injected dose per gram organ (% ID/g). Data are presented as mean ± SEM (n ≥ 3). *P < 0.05, versus 111In-DTPA, 111In-DTPA-AHNP, or 111In-DTPA-PEG group. b Comparison of tumor-to-muscle (T/M) and tumor-to-blood (T/B) ratios among 111In-DTPA, 111In-DTPA-AHNP, 111In-DTPA-PEG, and 111In-DTPA-AHNP-PEG injected mice after 1, 4, 24, and 48 h injection. Data are expressed as mean ± SEM (n ≥ 3). *P < 0.05, versus 111In-DTPA, 111In-DTPA-AHNP, or 111In-DTPA-PEG group

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