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Fig. 1 | Journal of Translational Medicine

Fig. 1

From: Polyethylene glycol-conjugated HER2-targeted peptides as a nuclear imaging probe for HER2-overexpressed gastric cancer detection in vivo

Fig. 1

HER2 levels in sera and tumors of GC patients. a The changes of serum HER2 (sHER2) levels in healthy subject (n = 32) and GC patients with stage 1–2 (n = 15) and stage 3–4 (n = 21) detected using an ELISA assay. *P < 0.05, **P < 0.01. b The HER2 protein expression in gastric tumor tissues responding the sHER2 levels. The tissues were selected from three high- and three low-level sHER2 of GC patients. c The HER2 protein expression in gastric tumors (T) and non-tumor tissues (NT) from the individual GC patients with high sHER2 levels. In b, c the protein expression was determined by Western blotting and quantified by densitometry and normalized by GAPDH levels. Data are presented as mean ± SEM (n = 3). *P < 0.05, versus low sHER2 levels of GC patients (b); *P < 0.05, versus non-tumor (c). d The sHER2 levels were correlated with the HER2 protein expressions in tumor tissues of GC patients. P < 0.01, tumor HER2 versus sHER2

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