Gene biomarkers | Pathways | Relevance to RA |
---|---|---|
MX1 | Cytokine signaling in immune system | Inflammatory cell infiltration Inflammation Synovial pannus formation |
Innate immune system | ||
Peginterferon alpha-2a/peginterferon alpha-2b pathway (Hepatocyte), pharmacodynamics | Drug metabolism | |
OASL | Cytokine signaling in Immune system | Inflammatory cell infiltration Inflammation Synovial pannus formation |
Innate immune system | ||
Immune response IFN alpha/beta signaling pathway | ||
Interferon signaling | ||
RNF2 | Cellular senescence | Drug metabolism |
SUMOylation of DNA damage response and repair proteins | ||
Metabolism of proteins | ||
Chromatin regulation/acetylation | ||
DNA damage | ||
SPINK1 | Regulation of peptidase activity | Inflammatory cell infiltration Inflammation Synovial pannus formation |
Nitric oxide mediated signal transduction | ||
Regulation of peptidyl-tyrosine phosphorylation | ||
CRK | RET signaling | Angiogenesis |
MET promotes cell motility | Joint destruction | |
Focal adhesion | Bone resorption | |
Integrin alphaIIb beta3 signaling | Angiogenesis | |
GRAPL | RET signaling | Angiogenesis |