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Table 3 Candidate gene biomarkers and the involved RA-related pathways

From: A novel gene-expression-signature-based model for prediction of response to Tripterysium glycosides tablet for rheumatoid arthritis patients

Gene biomarkers

Pathways

Relevance to RA

MX1

Cytokine signaling in immune system

Inflammatory cell infiltration

Inflammation

Synovial pannus formation

Innate immune system

Peginterferon alpha-2a/peginterferon alpha-2b pathway (Hepatocyte), pharmacodynamics

Drug metabolism

OASL

Cytokine signaling in Immune system

Inflammatory cell infiltration

Inflammation

Synovial pannus formation

Innate immune system

Immune response IFN alpha/beta signaling pathway

Interferon signaling

RNF2

Cellular senescence

Drug metabolism

SUMOylation of DNA damage response and repair proteins

Metabolism of proteins

Chromatin regulation/acetylation

DNA damage

SPINK1

Regulation of peptidase activity

Inflammatory cell infiltration

Inflammation

Synovial pannus formation

Nitric oxide mediated signal transduction

Regulation of peptidyl-tyrosine phosphorylation

CRK

RET signaling

Angiogenesis

MET promotes cell motility

Joint destruction

Focal adhesion

Bone resorption

Integrin alphaIIb beta3 signaling

Angiogenesis

GRAPL

RET signaling

Angiogenesis