Skip to main content

Advertisement

Table 3 Candidate gene biomarkers and the involved RA-related pathways

From: A novel gene-expression-signature-based model for prediction of response to Tripterysium glycosides tablet for rheumatoid arthritis patients

Gene biomarkers Pathways Relevance to RA
MX1 Cytokine signaling in immune system Inflammatory cell infiltration Inflammation Synovial pannus formation
Innate immune system
Peginterferon alpha-2a/peginterferon alpha-2b pathway (Hepatocyte), pharmacodynamics Drug metabolism
OASL Cytokine signaling in Immune system Inflammatory cell infiltration Inflammation Synovial pannus formation
Innate immune system
Immune response IFN alpha/beta signaling pathway
Interferon signaling
RNF2 Cellular senescence Drug metabolism
SUMOylation of DNA damage response and repair proteins
Metabolism of proteins
Chromatin regulation/acetylation
DNA damage
SPINK1 Regulation of peptidase activity Inflammatory cell infiltration Inflammation Synovial pannus formation
Nitric oxide mediated signal transduction
Regulation of peptidyl-tyrosine phosphorylation
CRK RET signaling Angiogenesis
MET promotes cell motility Joint destruction
Focal adhesion Bone resorption
Integrin alphaIIb beta3 signaling Angiogenesis
GRAPL RET signaling Angiogenesis