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Table 2 Network topological features and differential expression patterns of 16 major genes associated with RA patients’ response to TG tablets

From: A novel gene-expression-signature-based model for prediction of response to Tripterysium glycosides tablet for rheumatoid arthritis patients

Gene

Network topological features

Differential expression patterns

Degree

Closeness

Betweenness

P_value

Fold_change

Style

ACTL6B

2

2.69

1.37

0.04

0.82

Down

CRK

5

2.71

7.99

0.02

1.52

Up

GHR

3

2.69

1.37

0.03

1.25

Up

GRAPL

3

2.73

12.48

0.02

1.59

Up

IGF1

4

2.69

1.43

0.02

0.81

Down

MX1

5

2.72

11.21

0.02

0.55

Down

OASL

5

2.70

5.02

0.01

0.62

Down

RAB28

2

2.69

2.64

0.02

1.22

Up

RAB33B

2

2.66

1.37

0.02

1.24

Up

RNF2

3

2.68

2.64

0.02

1.65

Up

RNF8

2

2.66

1.37

0.04

0.80

Down

RPL23

3

2.67

1.37

0.04

0.79

Down

SPINK1

3

2.71

6.66

0.02

0.63

Down

UST

3

2.68

2.64

0.04

1.23

Up

VAV2

2

2.68

1.37

0.03

1.21

Up

ZNF384

2

2.66

1.37

0.01

1.23

Up

  1. The italic marks refer to the candidate gene biomarkers with high topological importance and high fold-change (> 1.5) of expression levels in responder and non-responder groups
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Journal of Translational Medicine

ISSN: 1479-5876

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