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Table 2 Network topological features and differential expression patterns of 16 major genes associated with RA patients’ response to TG tablets

From: A novel gene-expression-signature-based model for prediction of response to Tripterysium glycosides tablet for rheumatoid arthritis patients

Gene Network topological features Differential expression patterns
Degree Closeness Betweenness P_value Fold_change Style
ACTL6B 2 2.69 1.37 0.04 0.82 Down
CRK 5 2.71 7.99 0.02 1.52 Up
GHR 3 2.69 1.37 0.03 1.25 Up
GRAPL 3 2.73 12.48 0.02 1.59 Up
IGF1 4 2.69 1.43 0.02 0.81 Down
MX1 5 2.72 11.21 0.02 0.55 Down
OASL 5 2.70 5.02 0.01 0.62 Down
RAB28 2 2.69 2.64 0.02 1.22 Up
RAB33B 2 2.66 1.37 0.02 1.24 Up
RNF2 3 2.68 2.64 0.02 1.65 Up
RNF8 2 2.66 1.37 0.04 0.80 Down
RPL23 3 2.67 1.37 0.04 0.79 Down
SPINK1 3 2.71 6.66 0.02 0.63 Down
UST 3 2.68 2.64 0.04 1.23 Up
VAV2 2 2.68 1.37 0.03 1.21 Up
ZNF384 2 2.66 1.37 0.01 1.23 Up
  1. The italic marks refer to the candidate gene biomarkers with high topological importance and high fold-change (> 1.5) of expression levels in responder and non-responder groups