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Fig. 4 | Journal of Translational Medicine

Fig. 4

From: Immunosuppressive Treg cells acquire the phenotype of effector-T cells in chronic lymphocytic leukemia patients

Fig. 4

Innate and adaptive immune response-related gene abnormalities in CD4+ T cells of CLL patients. a Supervised clustering of differentially expressed genes in CD4+ T cells from HV (n = 10) and CLL patients (n = 10) (P < 0.05). b Fold regulation of significant differentially expressed genes. c Schematic representation of Tregs differentiation. Under differentiation stimuli, Tregs switched to effector-like Tregs, co-expressing FoxP3 and master transcription factors of effector-T cells and co-releasing IL-10 with inflammatory cytokines, such as IFN-γ and IL-4. However, Tregs did not show a TH17-like functional switch throughout the acquisition of RORγt transcription factor

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