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Fig. 1 | Journal of Translational Medicine

Fig. 1

From: Immunosuppressive Treg cells acquire the phenotype of effector-T cells in chronic lymphocytic leukemia patients

Fig. 1

Increased Tregs frequency in peripheral blood of CLL patients. a Gating strategy used to identify Tregs as CD4+CD25highFoxP3+. Representative box plots of b Tregs frequency in PBMCs obtained from HV (n = 15) and CLL patients (n = 15); c IL-10-secreting Tregs frequency in PBMCs obtained from HV (n = 15) and CLL patients (n = 15); d Tregs subsets frequency in PBMCs obtained from HV (n = 15) and CLL patients (n = 15), all after in vitro priming with IL-6 and phorbol 12-myristate 13-acetate (P), ionomycin (I) and monensin (M). All results are expressed as median and interquartile range. P value shown is obtained from the comparison between the indicated groups by exact non-parametric Mann–Whitney U test (*P < 0.05; **P < 0.01; ***P < 0.001)

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