Fig. 4

KLF5 knockdown suppressed hypoxia-induced DDP resistance by inhibiting HIF-1α-dependent glycolysis in NSCLC cells. A549 and H1299 cells were transfected with si-KLF5 or along with pcDNA-HIF-1α and incubated under a hypoxic condition. The protein levels of HIF-1α (a) and P-gp (b) in treated A549 and H1299 cells were determined by western blot. The glucose uptake (c) and lactate production (d) in treated A549 and H1299 cells were measured. *P < 0.05