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Table 3 Incidence and hazard ratio for bipolar disorders stratified by age, gender and comorbidity

From: Association of viral hepatitis and bipolar disorder: a nationwide population-based study

 

Comparison

N = 192,860

Hepatitis infection

Total (n = 48,215)

HBV (n = 34,459)

HCV (n = 9893)

Both (n = 3863)

Event no

%

Event no

%

HR† (95% CI)

Event no

%

HR† (95% CI)

Event no

%

HR† (95% CI)

Event no

%

HR† (95% CI)

Age, year

 20–49

87

1.14

38

2.01

1.35 (0.86, 2.11)

28

1.81

1.30 (0.80, 2.10)

5

2.28

1.17 (0.45, 3.03)

5

3.83

2.19 (0.85, 5.62)

 50–64

41

1.45

15

2.30

1.04 (0.53, 2.05)

8

2.05

0.98 (0.43, 2.21)

5

2.72

1.19 (0.44, 3.21)

2

2.58

1.02 (0.24, 4.46)

 65+

8

0.56

5

1.64

4.49 (1.25, 16.2)*

1

0.77

2.12 (0.25, 17.7)

2

1.49

4.58 (0.83, 25.4)

2

4.95

16.3 (2.83, 93.5)**

Gender

 Women

73

1.43

31

2.49

1.70 (1.06, 2.75)*

24

2.80

1.87 (1.13, 3.10)*

4

1.47

1.02 (0.35, 2.92)

3

2.63

1.80 (0.54, 5.94)

 Men

63

0.93

27

1.68

1.09 (0.65, 1.85)

13

1.08

0.76 (0.39, 1.46)

8

3.02

1.71 (0.77, 3.79)

6

4.46

2.42 (0.99, 5.96)

Comorbidity

 None

69

0.88

13

1.62

1.74 (0.96, 3.15)

11

1.63

1.74 (0.92, 3.31)

1

1.22

1.29 (0.18, 9.30)

1

2.38

2.54 (0.35, 18.3)

 With any one

67

1.66

45

2.20

1.19 (0.81, 1.76)

26

1.87

0.95 (0.59, 1.52)

11

2.42

1.46 (0.77, 2.77)

8

3.87

2.28 (1.09, 4.76)*

  1. %: Rate, per 10,000 person-years
  2. * p < 0.05, ** p < 0.01, *** p < 0.001
  3. † Multivariable analysis including age, sex, and comorbidities of cirrhosis, hypertension, hyperlipidemia, asthma, coronary artery disease, alcohol-related illness, anxiety, and major depressive disorders
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Journal of Translational Medicine

ISSN: 1479-5876

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