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Table 2 Univariate and multivariate analyses of OS in 74 patients with CRC patients

From: CHIP functions as an oncogene by promoting colorectal cancer metastasis via activation of MAPK and AKT signaling and suppression of E-cadherin

Characteristics Univariate analysis Multivariate analysis
HR (95%) CI P value HR (95%) CI P value
Age (≥ 60 vs. < 60) 1.504 (0.826–2.736) 0.182
Gender (male vs. female) 0.825 (0.480–1.416) 0.485
Differentiation (poor vs. well, moderate) 2.948 (1.618–5.369) < 0.001*** 3.030 (1.485–6.180) 0.002**
Site (right vs. left) 0.729 (0.410–1.296) 0.281
Depth of tumor invasion (T4 vs. T2, T3) 1.567 (0.801–3.066) 0.190
Lymph nodes invasion (N1, N2 vs. N0) 2.740 (1.557–4.820) < 0.001***
Metastasis (M1 vs. M0) 2.380 (0.850–6.667) 0.099
TNM stage (III, IV vs. I, II) 2.927 (1.640–5.222) < 0.001***
CHIP expression (high vs. low) 3.465 (1.561–7.693) 0.002** 7.163 (2.188–23.453) 0.001***
E-cadherin expression (high vs. low) 0.459 (0.249–0.847) 0.013*