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Table 1 The correlation of CHIP and E-cadherin expression with the clinical characteristics of CRC patients

From: CHIP functions as an oncogene by promoting colorectal cancer metastasis via activation of MAPK and AKT signaling and suppression of E-cadherin

Characteristics Nr. of patients (total: 93) CHIP expression E-cadherin expression
High Low P value High Low P value
Nr. (N = 67) Nr. (N = 26) Nr. (N = 36) Nr. (N = 57)
Age (years) 68 (22–93)    0.231    0.210
 ≤ 60 34 22 12   16 18  
 > 60 59 45 14   20 39  
Gender     0.830    0.422
 Male 52 37 15   22 30  
 Female 41 30 11   14 27  
Site     0.708    0.099
 Right 34 25 9   10 24  
 Left 53 37 16   25 28  
 Unknown 6 5 1   1 5  
Differentiation     0.456    0.32
 Well 2 2 0   2 0  
 Moderate 73 53 20   28 45  
 Poor 18 12 6   6 12  
Depth of tumor invasion     0.039*    0.048*
 T1 0 0 0   0 0  
 T2 5 2 3   3 2  
 T3 64 44 20   27 37  
 T4 16 14 2   3 13  
 Unknown 8 7 1   3 5  
Lymph nodes invasion     0.003**    0.043*
 N0 51 33 18   24 27  
 N1 28 25 3   7 21  
 N2 9 8 0   2 6  
 Unknown 6 1 5   3 3  
Metastasis     0.481    0.960
 M0 89 63 26   35 54  
 M1 4 4 0   1 3  
TNM stage     0.003**    0.020*
 I 4 2 2   3 1  
 II 41 26 15   19 22  
 III 35 31 4   9 26  
 IV 4 4 0   1 3  
 Unknown 9 4 5   4 5