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Fig. 6 | Journal of Translational Medicine

Fig. 6

From: CHIP functions as an oncogene by promoting colorectal cancer metastasis via activation of MAPK and AKT signaling and suppression of E-cadherin

Fig. 6

Schematic representation of CHIP in the modulation of EMT in CRC. CHIP activated the MAPK and AKT signaling pathway, which resulted in the inactivation of GSK-3β by phosphorylation at ser9. Consequently, the GSK-3β inactivation upregulated Slug and resulted in the decreased expression of E-cadherin by transcriptional repression

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