Fig. 6From: CHIP functions as an oncogene by promoting colorectal cancer metastasis via activation of MAPK and AKT signaling and suppression of E-cadherinSchematic representation of CHIP in the modulation of EMT in CRC. CHIP activated the MAPK and AKT signaling pathway, which resulted in the inactivation of GSK-3β by phosphorylation at ser9. Consequently, the GSK-3β inactivation upregulated Slug and resulted in the decreased expression of E-cadherin by transcriptional repressionBack to article page