Fig. 5
Clinical significance of CHIP and E-cadherin expression in CRC tissues. a Representative images of CHIP and E-cadherin expression in CRC and adjacent non-neoplastic tissues were shown by IHC. Tumor represented CRC cancer tissues; Adjacent represented the non-neoplastic tissues; magnification ×100 and ×200). Higher expression of CHIP was observed in the membrane and cytoplasm of CRC cells compared to that of the adjacent counterparts. E-cadherin was weekly positive or negative in the membrane and the cytoplasm of CRC cells. However, the majority of the adjacent counterparts cells were E-cadherin positive. b, c The stacked bars indicate the percentages of CRC samples with high and low CHIP and E-cadherin expression levels relative to the total number of tissues (χ2 test, ***P < 0.001). d The stacked bars indicate the percentages of CRC samples with high and low E-cadherin expression levels relative to the total number of CHIP-high and CHIP-low sections, respectively (Spearman’s test, ***P < 0.001). e Kaplan–Meier curves that depict the 5-year overall survival according to the CHIP expression in patients with CRC (n = 93, P = 0.001). CHIP-low represented the CHIP low expression group; CHIP-high represented the CHIP high expression group. The differences of the overall survival between these two groups were determined using a log-rank test. f Kaplan–Meier curves that depict the 5-year overall survival according to the CHIP expression in patients with CRC (n = 93, P = 0.010). E-cadherin-low represented the E-cadherin low expression group; E-cadherin-high represented the E-cadherin high expression group. The difference of the overall survival between these two groups was determined using a log-rank test