Skip to main content

Table 2 Variables associated with the presence of significant necroinflammatory activity (score 4–18) in the training group (401 patients) by univariate analyses cohort

From: Prediction of hepatic necroinflammatory activity in patients with chronic hepatitis B by a simple noninvasive model

Variables

No significant inflammation (n = 163)

Significant inflammation (n = 238)

P value

Age (year)

32 (25–40)

34 (27–41.25)

0.114

Weight (kg)

64 (58–69)

61 (56–66)

0.013

Male (n)

128 (78.5%)

194 (81.5%)

0.523b

RBC (1012/L)

4.8 (4.2–5.4)

4.8 (4.3–5.5)

0.119

WBC (109/L)

5 (4.5–5.625)

4.95 (4.3–5.5)

0.056

PLT (109/L)

147 (110–193)

141.5 (109–192)

0.78

HB (g/L)

141 (131–154)

139.5 (129–152.25)

0.533

TG (mmol/L)

1.2 (0.8–1.5)

1.2 (0.9–1.5)

0.793

TC (mmol/L)

4.3 (3.9–5)

4.1 (3.5–4.7)

0.005

ALT (IU/L)

64 (42–85)

95.5 (55–209.75)

< 0.001a

AST (IU/L)

46 (30–67)

72 (42–139)

< 0.001a

GGT (IU/L)

32 (20–54)

108.57 ± 94.57

< 0.001a

ALP (IU/L)

72 (60–88)

87.5 (70–117)

< 0.001a

TB (μmol/L)

12.9 (10.4–17.6)

15.9 (11.4–24.45)

< 0.001a

DB (μmol/L)

4.4 (3.2–6)

5.85 (3.9–9.7)

< 0.001a

ALB (g/L)

45 (41–48.2)

39 (36–43.725)

< 0.001

AFP (ng/mL)

3 (2.3–4.5)

4.75 (3.1–11)

< 0.001a

PT (s)

12.1 (11.5–12.8)

12.8 (12–13.725)

< 0.001a

HBVDNA (log10 copies/mL)

5.43 (3–6.64)

5.8 (4.08–6.98)

0.063a

  1. RBC red blood cell, WBC white blood cell, PLT platelets, HB haemoglobin, TG triglyceride, TC total cholesterol, ALT alanine aminotransferase, AST aspartate aminotransferase, GGT γ-glutamyl transpeptidase, ALP alkaline phosphatase, TB total bilirubin, DB indirect bilirubin, ALB albumin, AFP α-fetal protein, PT prothrombin time
  2. a Values are comparisons between the training and validation set using an independent samples t test, except nonparametric test
  3. b Values are comparisons between the training and validation set using an independent samples t test, except x2 test