Fig. 5

Cell viability assay results for doxorubicin treatment and miR-197 transfection in diffuse large B-cell lymphoma cell lines. Upon treatment with a series of doxorubicin concentrations in diffuse large B-cell lymphoma cells of non-germinal center/activated B cell-like (non-GCB/ABC; SUDHL9) phenotype and GCB origin (OCI-LY1), cell viability was significantly reduced in the miR-197 transfection group compared with that in the scrambled control group. SUDHL9, an ABC DLBCL cell line, exhibited significant miR-197-transfection-induced reduction in cell viability at lower concentrations of doxorubicin (a) compared with OCI-Ly1, a GCB DLBCL cell line (b)