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Table 1 Clinicopathologic correlation of GEP expression in colorectal cancer (n = 190, significant P-value in italic format)

From: Granulin epithelin precursor promotes colorectal carcinogenesis by activating MARK/ERK pathway

  GEP expression (n = 190) P-value
All H-score ≥ 150 H-score < 150
98 (51.6%) 92 (48.4%)
Male gender 106 (55.8%) 51 (52.0%) 55 (59.8%) 0.283
Age at operation (years, mean ± SD) 67.4 ± 12.1 66.7 ± 12.6 68.2 ± 11.6 0.386
Location     0.032
 Right colon 51 (26.8%) 27 (29.0%) 24 (26.4%)  
 Left colon 36 (18.9%) 23 (24.7%) 13 (14.3%)  
 Rectum 88 (46.3%) 36 (38.7%) 52 (57.1%)  
 Synchronous 9 (4.7%) 7 (7.5%) 2 (2.2%)  
 Unknown 6 (3.2%) / /  
Size (cm, mean ± SD) 4.5 ± 1.7 4.6 ± 1.9 4.3 ± 1.6 0.257
Differentiation     
 Well 2 (1.1%) 0 2 (2.2%) 0.052
 Moderate 180 (94.7%) 92 (95.8%) 88 (97.8%)  
 Poor 4 (2.1%) 4 (4.2%) 0  
 Others 4 (2.1%) / /  
AJCC stage     < 0.01
 I 17 (8.9%) 5 (5.1%) 12 (13.0%)  
 II 57 (30.0%) 19 (19.4%) 38 (41.3%)  
 III 56 (29.5%) 27 (27.6%) 29 (31.5%)  
 IV 60 (31.6%) 47 (48.0%) 13 (14.1%)  
T stage     0.583
 T1 5 (2.6%) 3 (3.1%) 2 (2.2%)  
 T2 19 (10.0%) 8 (8.2%) 11 (12.0%)  
 T3 122 (64.2%) 61 (62.2%) 61 (66.3%)  
 T4 44 (23.2%) 26 (26.5%) 18 (19.8%)  
N stage     < 0.01
 N0 89 (46.8%) 35 (35.7%) 54 (58.7%)  
 N1 61 (32.1%) 34 (34.7%) 27 (29.3%)  
 N2 40 (21.1%) 29 (29.6%) 11 (12.0%)  
M stage     < 0.01
 M0 129 (67.9%) 50 (51.0%) 79 (85.9%)  
 M1 61 (32.1%) 48 (49.0%) 13 (14.1%)  
Pre-ops CEA (ng/ml, mean ± SD) 142.0 ± 838.4 218.9 ± 1118.1 53.4 ± 256.5 0.194