Table 1 Clinicopathologic correlation of GEP expression in colorectal cancer (n = 190, significant P-value in italic format)
From: Granulin epithelin precursor promotes colorectal carcinogenesis by activating MARK/ERK pathway
|  | GEP expression (n = 190) | P-value | ||
|---|---|---|---|---|
All | H-score ≥ 150 | H-score < 150 | ||
98 (51.6%) | 92 (48.4%) | |||
Male gender | 106 (55.8%) | 51 (52.0%) | 55 (59.8%) | 0.283 |
Age at operation (years, mean ± SD) | 67.4 ± 12.1 | 66.7 ± 12.6 | 68.2 ± 11.6 | 0.386 |
Location | Â | Â | Â | 0.032 |
 Right colon | 51 (26.8%) | 27 (29.0%) | 24 (26.4%) |  |
 Left colon | 36 (18.9%) | 23 (24.7%) | 13 (14.3%) |  |
 Rectum | 88 (46.3%) | 36 (38.7%) | 52 (57.1%) |  |
 Synchronous | 9 (4.7%) | 7 (7.5%) | 2 (2.2%) |  |
 Unknown | 6 (3.2%) | / | / |  |
Size (cm, mean ± SD) | 4.5 ± 1.7 | 4.6 ± 1.9 | 4.3 ± 1.6 | 0.257 |
Differentiation | Â | Â | Â | Â |
 Well | 2 (1.1%) | 0 | 2 (2.2%) | 0.052 |
 Moderate | 180 (94.7%) | 92 (95.8%) | 88 (97.8%) |  |
 Poor | 4 (2.1%) | 4 (4.2%) | 0 |  |
 Others | 4 (2.1%) | / | / |  |
AJCC stage |  |  |  | < 0.01 |
 I | 17 (8.9%) | 5 (5.1%) | 12 (13.0%) |  |
 II | 57 (30.0%) | 19 (19.4%) | 38 (41.3%) |  |
 III | 56 (29.5%) | 27 (27.6%) | 29 (31.5%) |  |
 IV | 60 (31.6%) | 47 (48.0%) | 13 (14.1%) |  |
T stage | Â | Â | Â | 0.583 |
 T1 | 5 (2.6%) | 3 (3.1%) | 2 (2.2%) |  |
 T2 | 19 (10.0%) | 8 (8.2%) | 11 (12.0%) |  |
 T3 | 122 (64.2%) | 61 (62.2%) | 61 (66.3%) |  |
 T4 | 44 (23.2%) | 26 (26.5%) | 18 (19.8%) |  |
N stage |  |  |  | < 0.01 |
 N0 | 89 (46.8%) | 35 (35.7%) | 54 (58.7%) |  |
 N1 | 61 (32.1%) | 34 (34.7%) | 27 (29.3%) |  |
 N2 | 40 (21.1%) | 29 (29.6%) | 11 (12.0%) |  |
M stage |  |  |  | < 0.01 |
 M0 | 129 (67.9%) | 50 (51.0%) | 79 (85.9%) |  |
 M1 | 61 (32.1%) | 48 (49.0%) | 13 (14.1%) |  |
Pre-ops CEA (ng/ml, mean ± SD) | 142.0 ± 838.4 | 218.9 ± 1118.1 | 53.4 ± 256.5 | 0.194 |