Fig. 5
From: Granulin epithelin precursor promotes colorectal carcinogenesis by activating MARK/ERK pathway
GEP promotes carcinogenesis via MAPK/ERK pathway in CRC. a A serial of promoter-luciferase assays (p53, TGFβ, Cell cycle, Myc, Hypoxia, MAPK/ERK, NF-κB and Wnt) were performed to screen for GEP target signaling pathways in DLD-1 and HCT 116 cells with GEP knockdown cells. b Western blot showed significant suppression of phospho-MAPK/ERK in the siGEP-treated CRC tumors cells compared with control. c GEP was shown to upregulate the phosphorylation of MAPK/ERK, nucleus translocation and stimulate cell proliferation, cell survival and metastasis of CRC. (*P < 0.05; **P < 0.01)