Fig. 3

GEP exerts oncogenic function in CRC cells. a GEP showed decreased expression at the mRNA level by qRT-PCR in DLD-1 and HCT 116 cells. b A significantly decreased proliferation was observed in the siGEP treated group compared with siControl group in all 2 cell lines examined (P < 0.01). c GEP knockdown significantly reduced anchorage-dependent growth in CRC cell lines by Foci-Formation assay (P < 0.01). d, e Knockdown GEP expression by siRNA eliminated the ability of the and invasion (d) and migration (e) in both DLD-1 and HCT 116 cells compared to the control group. f Pictures of tumors isolated from nude mice at the end of investigation (Left); The tumor growth was monitored and calculated in the line chart (Middle) and histogram represented mean of the tumor weight (Right) from the shControl and shGEP groups. (*P < 0.05; **P < 0.01)