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Table 2 Multiple regression analysis of methylation levels of the ADRB3 gene with lipid profile and oxidative stress of adult individuals by nutritional status

From: Decrease of the DNA methylation levels of the ADRB3 gene in leukocytes is related with serum folate in eutrophic adults

  Coefficient CI 95% Statistics t p-value
Total cholesterol (mg/dl)
 Eutrophic* 0.23 (− 0.10 ± 0.56) 0.69 0.4999
 Overweight 0.06 (− 0.04 ± 0.15) 0.61 0.5442
 Obesity − 0.13 (− 0.24 ± − 0.01) − 1.06 0.3000
LDL (mg/dl)
 Eutrophic* − 0.47 (− 0.82 ± − 0.11) − 1.31 0.2051
 Overweight − 0.02 (− 0.09 ± 0.04) − 0.38 0.7087
 Obesity 0.12 (0.03 ± 0.21) 1.35 0.1910
HDL (mg/dl)
 Eutrophic* 0.41 (− 0.16 ± 0.97) 0.72 0.4808
 Overweight 0.27 (− 0.02 ± 0.56) 0.92 0.3639
 Obesity 0.06 (− 0.49 ± 0.60) 0.12 0.9160
Triglycerides (mg/dl)
 Eutrophic* 0.08 (− 0.06 ± 0.22) 0.54 0.5941
 Overweight 0.02 (− 0.01 ± 0.05) 0.57 0.5742
 Obesity 0.02 (− 0.04 ± 0.08) 0.36 0.720
TAC (%)
 Eutrophic* 27.64 (− 8.54 ± 63.83) 0.76 0.4543
 Overweight 11.30 (− 8.87 ± 31.48) 0.56 0.5789
 Obesity 17.42 (− 7.63 ± 42.47) 0.70 0.4940
MDA
 Eutrophic* − 4.55 (− 1.37 ± 10.48) 0.77 0.4516
 Overweight − 8.07 (− 12.60 ± − 3.53) − 1.78 0.0839
 Obesity − 1.54 (− 6.81 ± 3.72) − 0.29 0.7720
Alpha-1 acid glycoprotein (mg/dl)
 Eutrophic* 0.23 (0.02 ± 0.44) 1.07 0.2964
 Overweight 0.00 (− 0.18 ± 0.19) 0.02 0.9880
 Obesity 0.08 (− 0.16 ± 0.32) 0.33 0.7420
Homocysteine (micromol/l)
 Eutrophic* − 1.74 (− 3.50 ± 0.01) − 0.99 0.3339
 Overweight − 0.45 (− 0.82 ± − 0.08) − 1.20 0.2368
 Obesity − 0.54 (− 1.02 ± − 0.06) − 1.12 0.2750
Serum folate (ng/ml)
 Eutrophic* − 2.27 (− 3.26 ± − 1.28) − 2.30 0.0327*
 Overweight − 0.79 (− 1.53 ± − 0.05) − 1.06 0.2956
 Obesity − 0.44 (− 1.13 ± 0.25) − 0.63 0.5330
Vitamin B12 (pg/ml)
 Eutrophic* 6.65 (2.72 ± 10.58) 1.69 0.1067
 Overweight 3.67 (1.21 ± 6.14) 1.49 0.1452
 Obesity − 0.32 (− 2.80 ± 2.16) − 0.13 0.8970
  1. * Eutrophic: after adjustment for sex and age significant relationships remained for methylation levels and male gender