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Table 2 Multiple regression analysis of methylation levels of the ADRB3 gene with lipid profile and oxidative stress of adult individuals by nutritional status

From: Decrease of the DNA methylation levels of the ADRB3 gene in leukocytes is related with serum folate in eutrophic adults

 

Coefficient

CI 95%

Statistics t

p-value

Total cholesterol (mg/dl)

 Eutrophic*

0.23

(− 0.10 ± 0.56)

0.69

0.4999

 Overweight

0.06

(− 0.04 ± 0.15)

0.61

0.5442

 Obesity

− 0.13

(− 0.24 ± − 0.01)

− 1.06

0.3000

LDL (mg/dl)

 Eutrophic*

− 0.47

(− 0.82 ± − 0.11)

− 1.31

0.2051

 Overweight

− 0.02

(− 0.09 ± 0.04)

− 0.38

0.7087

 Obesity

0.12

(0.03 ± 0.21)

1.35

0.1910

HDL (mg/dl)

 Eutrophic*

0.41

(− 0.16 ± 0.97)

0.72

0.4808

 Overweight

0.27

(− 0.02 ± 0.56)

0.92

0.3639

 Obesity

0.06

(− 0.49 ± 0.60)

0.12

0.9160

Triglycerides (mg/dl)

 Eutrophic*

0.08

(− 0.06 ± 0.22)

0.54

0.5941

 Overweight

0.02

(− 0.01 ± 0.05)

0.57

0.5742

 Obesity

0.02

(− 0.04 ± 0.08)

0.36

0.720

TAC (%)

 Eutrophic*

27.64

(− 8.54 ± 63.83)

0.76

0.4543

 Overweight

11.30

(− 8.87 ± 31.48)

0.56

0.5789

 Obesity

17.42

(− 7.63 ± 42.47)

0.70

0.4940

MDA

 Eutrophic*

− 4.55

(− 1.37 ± 10.48)

0.77

0.4516

 Overweight

− 8.07

(− 12.60 ± − 3.53)

− 1.78

0.0839

 Obesity

− 1.54

(− 6.81 ± 3.72)

− 0.29

0.7720

Alpha-1 acid glycoprotein (mg/dl)

 Eutrophic*

0.23

(0.02 ± 0.44)

1.07

0.2964

 Overweight

0.00

(− 0.18 ± 0.19)

0.02

0.9880

 Obesity

0.08

(− 0.16 ± 0.32)

0.33

0.7420

Homocysteine (micromol/l)

 Eutrophic*

− 1.74

(− 3.50 ± 0.01)

− 0.99

0.3339

 Overweight

− 0.45

(− 0.82 ± − 0.08)

− 1.20

0.2368

 Obesity

− 0.54

(− 1.02 ± − 0.06)

− 1.12

0.2750

Serum folate (ng/ml)

 Eutrophic*

− 2.27

(− 3.26 ± − 1.28)

− 2.30

0.0327*

 Overweight

− 0.79

(− 1.53 ± − 0.05)

− 1.06

0.2956

 Obesity

− 0.44

(− 1.13 ± 0.25)

− 0.63

0.5330

Vitamin B12 (pg/ml)

 Eutrophic*

6.65

(2.72 ± 10.58)

1.69

0.1067

 Overweight

3.67

(1.21 ± 6.14)

1.49

0.1452

 Obesity

− 0.32

(− 2.80 ± 2.16)

− 0.13

0.8970

  1. * Eutrophic: after adjustment for sex and age significant relationships remained for methylation levels and male gender