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Fig. 5 | Journal of Translational Medicine

Fig. 5

From: Baseline immune profile by CyTOF can predict response to an investigational adjuvanted vaccine in elderly adults

Fig. 5

PCA analysis on gated subsets. a Multivariate analysis of cytokine responses and phenotype marker levels in the study groups at day 0, before vaccination. “Orthogonal partial least square-discriminant analysis” (OPLS-DA) was done to see if the cytokine responses and markers (X-variables) could segregate the two study groups (Y-variables, e.g. non-responders (n = 5) and responders (n = 14) before vaccine against RSV was given. The generated model had a stability of 44% (Q2Y = 0.44) and explanatory power of 66% (a goodness of fit R2Y = 0.66). b Column graph of the OPLS-DA was done to see which variables had the largest impact on the separation of the two groups (responders and non-responders at day 0). Variables closest to the subject group are positively associated

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