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Table 2 Flow cytometric landscape of the MO 3 months after CPB compared to pre-CPB levels

From: Acquired immunological imbalance after surgery with cardiopulmonary bypass due to epigenetic over-activation of PU.1/M-CSF

Marker

Typical cellular expression

to (Me [IQ25; IQ75])

t3m (Me [IQ25; IQ75])

p

MFI-MRP8

MAC M1

2372.33 [1250.74, 2977.14]

774.4 [695.33, 1032.22]

0.019

MFI CD86

Activated MO

783.88 [457.60, 990.84]

230.17 [178.29, 372.42]

0.050

MFI-CD206

MAC M2

725.00 [409.81, 1038.23]

1902.2 [905.26, 4212.51]

0.026

MFI-CD163

MAC M1

1653.80 [1400.21, 1885.59]

1335.6 [718.19, 1439.18]

0.004

TGF/LAP

MAC M2

1099.53 [892.44, 1253.50]

3223 [2407.00, 3560.50]

0.003

  1. Flow cytometry reveals a persistence of MRP(high), CD206(high), CD163(high), TGF/LAP(high) and decreased expression of CD86 3 months after CPB as compared to pre-CPB values