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Fig. 3 | Journal of Translational Medicine

Fig. 3

From: CD8+ T cells mediate the antitumor activity of frankincense and myrrh in hepatocellular carcinoma

Fig. 3

An intact immune system is indispensable to the antitumor efficacy of FM. 4–6-week-old male (a) Balb/c nude mice received subcutaneous injection of 1 × 107 HCCLM3 cells, or (d) C57BL/6 mice received 5 × 106 Hepa1-6 cells in the right flank. When tumor size reached about 4–6 mm in diameter, mice were randomly divided into two groups. Then the mice were either treated daily with oral gavage of FM at a dose of 60 mg/kg, or left untreated as a control (n = 8 in each group). Tumor volumes (a, d) were measured by caliper and body weight (b, e) were monitored every 2–3 days during the treatment. Mean ± SD of each group are shown. Mice were sacrificed when tumor volume reached 2 cm3, or when mice appeared moribund. c, f Survival was determined and plotted for Kaplan–Meier survival analysis and analyzed by log-rank test. #p > 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001

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