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Table 3 Top ten significant GO terms enriched by targets of the identified microRNA biomarkers

From: Biomarker microRNAs for prostate cancer metastasis: screened with a network vulnerability analysis model

Category

GO terms

Number of enriched genes

Adj.p value

BP

Mitotic cell cycle

60

3.52E−07

Phosphorus metabolic process

112

4.00E−06

Phosphate metabolic process

112

4.00E−06

Regulation of apoptosis

97

3.51E−06

Positive regulation of cell proliferation

61

2.83E−06

Cell cycle process

75

3.16E−06

Regulation of programmed cell death

97

2.92E−06

Regulation of cell death

97

3.02E−06

Cell cycle

93

4.11E−06

Regulation of transcription from RNA polymerase II promoter

88

6.10E−06

CC

Nuclear lumen

162

1.17E−13

Nucleoplasm

110

7.25E−12

Organelle lumen

182

1.05E−11

Membrane-enclosed lumen

183

2.45E−11

Intracellular organelle lumen

176

5.37E−11

Nucleoplasm part

77

1.95E−10

Intracellular non-membrane-bounded organelle

212

5.33E−06

Non-membrane-bounded organelle

212

5.33E−06

Chromatin remodeling complex

18

3.26E−05

Nucleolus

72

1.81E−04

MF

Transcription regulator activity

163

1.16E−09

Transcription repressor activity

50

1.35E−06

Transcription factor binding

67

4.45E−06

Transcription activator activity

56

1.36E−05

Transcription factor activity

100

1.41E−04

Protein kinase activity

68

5.01E−04

Transcription cofactor activity

46

1.07E−03

Protein serine/threonine kinase activity

50

3.67E−03

DNA binding

190

5.00E−03

Phosphoprotein phosphatase activity

25

8.40E−03

  1. GO gene ontology; BP biological process; CC cellular component; MF molecular function; adj.p value: adjusted p value