Table 1 Epidemiological and clinical data of affected family members
Family Member | Diagnosis age | Histological subtype | SBR grade | Tumor size (mm) | Hormone receptors status | HER2 status | Disease evolution | Medical history |
|---|---|---|---|---|---|---|---|---|
BC-TN-F001-1 | 43 | Invasive ductal carcinoma | II | 22 | ER +/PR+ | ND | CBC within 5 years, grade III triple negative carcinoma | 3 miscarriages |
BC-TN-F001-2 | 56 | Invasive ductal carcinoma | ND | ND | ER +/PR+ | ND | In remission | No medical history |
BC-TN-F001-3 | 47 | Bifocal invasive ductal carcinoma | I | 7 | ER +/PR+ | HER2− | In remission | Primary infertility (IVF) |