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Table 2 Pharmacokinetic parameters in monkey following single oral doses of MIV-711

From: Nonclinical and clinical pharmacological characterization of the potent and selective cathepsin K inhibitor MIV-711

Dose (µmol/kg)

Cmax (µmol/L)

AUC0–t (µmol/L × h)

AUCinf (µmol/L × h)

t½ (h)

t amax (h)

Cmax/dose

n

3

0.102 (65)

0.400 (60)

0.409 (62)

2.1 (16)

2.0 (2.0–2.0)

0.034 (65)

4

10

0.164 (41)

0.881 (52)

0.932 (46)

3.1 (52)

2.0 (0.50–4.0)

0.016 (41)

9

30

0.923 (56)

6.21 (62)

6.28 (62)

3.4 (30)

2.0 (1.0–4.0)

0.031 (56)

11

  1. Data are presented as geometric mean (CV%)
  2. aMedian (min–max)