Fig. 4

Urine biomarker concentrations in response to single or repeat oral dosing once daily for 5 days with vehicle or MIV-711 (30 µmol/kg). Biomarkers in the graph were measured in urine samples collected between 0–4, 4–8 and 8–24 h after dose on Day 1 and Day 5 of vehicle and MIV-711 treatment. The mean value of the concentrations measured in the three samples collected was calculated. Mean ± SEM, n = 4. *p < 0.05 versus corresponding vehicle