Fig. 1

Effect of MIV-711 on human osteoclast-mediated bone resorption using human bone fragments. Control cells exposed to medium without inhibitor were set to 100%. CTX-I levels from MIV-711-treated cells were normalized and expressed as % of control. Data are from two osteoclast preparations with each preparation measured in triplicate (n = 6). The data were fitted to the Hill equation. Mean ± SEM