Skip to main content
Fig. 6 | Journal of Translational Medicine

Fig. 6

From: Connexin32 plays a crucial role in ROS-mediated endoplasmic reticulum stress apoptosis signaling pathway in ischemia reperfusion-induced acute kidney injury

Fig. 6

Cx32 gene deletion markedly attenuated I/R-induced renal tubular epithelial cells apoptosis and damage. a Cx32 gene deletion remarkably reduced I/R (24 h)-induced renal tubular epithelial cells apoptosis of kidneys. Representative TUNEL apoptosis assay images of kidney tissues. Brown dots were deemed positive apoptosis cells (magnification ×400; red arrow). b Histopathologic examination (magnification ×200). c Histopathologic scores of kidneys, n = 6, *p < 0.05 vs (Cx32+/+) +Sham group; #p < 0.05 vs (Cx32+/+) + I/R group. Data are the mean values ± SEM. d Cx32 gene deletion significant decreased plasma BUN and Cre levels after renal I/R at the time point of 24 h, n = 6, *p < 0.05 vs (Cx32+/+) +Sham group; #p < 0.05 vs (Cx32+/+) + I/R group. Data are the mean values ± SEM

Back to article page