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Fig. 4 | Journal of Translational Medicine

Fig. 4

From: Connexin32 plays a crucial role in ROS-mediated endoplasmic reticulum stress apoptosis signaling pathway in ischemia reperfusion-induced acute kidney injury

Fig. 4

NAC pretreatment diminished ROS production, ERS-related proteins expression and apoptosis or damage. a NAC (200 mg/kg, 1 h) pretreatment reduced I/R (24 h)-induced ROS generation. DHE staining was used to detect the level of ROS (magnification ×200). b NAC pretreatment directly inhibited the I/R (24 h)-induced ERS-related proteins expression (GRP78, XBP1 and CHOP). c NAC pretreatment attenuated I/R (24 h)-induced apoptosis of kidneys. Brown dots were deemed positive apoptosis cells (magnification ×400; red arrow). d, e NAC pretreatment reduced renal injury (magnification ×200) and f decreased plasma BUN and Cre levels, n = 6, *p < 0.05 vs Sham group, #p < 0.05 vs I/R group. Data are the mean values ± SEM

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