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Table 1 Performances of static and dynamic serum CA125 test-based diagnostic criteria for early-stage ovarian cancer

From: Postprandial increase in serum CA125 as a surrogate biomarker for early diagnosis of ovarian cancer

Diagnostic criteria Sensitivity (%) Specificity (%) PPV (%) NPV (%) Youden’s index
CA125 alone
 Random CA125 ≥ 35 U/mL 75.0 25.4 6.6 93.6 0.004
 Fasting CA125 ≥ 35 U/mL 72.2 25.8 6.4 93.0 -0.020
 Postprandial CA125 ≥ 35 U/mL 77.8 25.0 6.8 94.2 0.028
 Random CA125 ≥ 20 U/mL 91.6 14.0 6.9 97.1 0.056
 Fasting CA125 ≥ 20 U/mL 91.7 13.2 6.9 95.8 0.049
 Postprandial CA125 ≥ 20 U/mL 94.4 13.0 7.1 96.0 0.075
CA125 postprandial increment alone
 CA125 increment ≥ 10% 83.3 96.3 61.1 98.8 0.796
CA125 and postprandial increment combined
 Fasting CA125 ≥ 20 U/mL and CA125 increment ≥ 10% 77.8 97.5 68.1 98.4 0.752
SVM-based CA125-increment algorithm
 σ = 25, fasting CA125 and postprandial increment as inputs 91.7 99.2 89.2 99.4 0.924