Table 1 Performances of static and dynamic serum CA125 test-based diagnostic criteria for early-stage ovarian cancer
From: Postprandial increase in serum CA125 as a surrogate biomarker for early diagnosis of ovarian cancer
Diagnostic criteria | Sensitivity (%) | Specificity (%) | PPV (%) | NPV (%) | Youden’s index |
|---|---|---|---|---|---|
CA125 alone | |||||
 Random CA125 ≥ 35 U/mL | 75.0 | 25.4 | 6.6 | 93.6 | 0.004 |
 Fasting CA125 ≥ 35 U/mL | 72.2 | 25.8 | 6.4 | 93.0 | -0.020 |
 Postprandial CA125 ≥ 35 U/mL | 77.8 | 25.0 | 6.8 | 94.2 | 0.028 |
 Random CA125 ≥ 20 U/mL | 91.6 | 14.0 | 6.9 | 97.1 | 0.056 |
 Fasting CA125 ≥ 20 U/mL | 91.7 | 13.2 | 6.9 | 95.8 | 0.049 |
 Postprandial CA125 ≥ 20 U/mL | 94.4 | 13.0 | 7.1 | 96.0 | 0.075 |
CA125 postprandial increment alone | |||||
 CA125 increment ≥ 10% | 83.3 | 96.3 | 61.1 | 98.8 | 0.796 |
CA125 and postprandial increment combined | |||||
 Fasting CA125 ≥ 20 U/mL and CA125 increment ≥ 10% | 77.8 | 97.5 | 68.1 | 98.4 | 0.752 |
SVM-based CA125-increment algorithm | |||||
 σ = 25, fasting CA125 and postprandial increment as inputs | 91.7 | 99.2 | 89.2 | 99.4 | 0.924 |