Table 1 Characteristics of immunocompromised mouse strains
From: Patient-derived xenograft models in musculoskeletal malignancies
Mouse strain | Characteristics | Advantages | Applications | ||||
|---|---|---|---|---|---|---|---|
T cells | B cells | NK cells | GNs | DCs | |||
Nude | ± | + | ± | + | Low cost Long life span Hairless; easy assessment of tumor volume | Cell line engraftment and patient-derived tumor xenografts Microbiology and immunology research | |
Scid | − | − | + | + | + | Severe immune deficiency | Cell line engraftment and patient-derived tumor xenografts Infection and immunology research Spontaneous development and metastasis of thymic lymphoma |
NS | − | − | ± | ± | ± | Imparied NK cell, DC, and myeloid cell functions Higher engraftment rates of cell lines than in scid or nude mice | Cell line and patient-derived tumor xenografts Infection and immunology research Hematological malignancy research Spontaneous development and metastasis of thymic lymphoma |
NSG (NOG) | − | − | − | ± | ± | Absence of NK cells; the most severely immunodeficient mice High engraftment rates of tumor cell lines and tissues Longer life span than NOD-Scid mice No T/B cell leakage | Widest range of solid and hematologic tumor engraftment Infection and immunology research Humanized model development |