Fig. 1
From: Role of p53/miR-155-5p/sirt1 loop in renal tubular injury of diabetic kidney disease
High glucose can promote the expression of miR-155-5p in HK-2 cells in concentration gradient, a inhibit the expression of Sirt1, autophagy-related index, promote P53 and promote the expression of fibrosis molecules. b QRT-PCR and c western blot with d quantitative analysis of Sirt1, P53, LC3 II, p62, FN and Col-1 expression in HK-2 cells treated with high glucose (30 mM) for 72 h. Results are presented as mean ± SEM of three independent experiments. *P < 0.05 vs NG, NG normal glucose (5.5 mM)