Table 2 Shortlisted differentially expressed proteins following the same expression trend in both discovery and test sets

Q96M60

Protein FAM227B

7.58E−04

0.38

8.11E−03

Q03164

Histone-lysine N-methyltransferase 2A

9.84E−04

0.12

8.11E−03

Q9NVW2

E3 ubiquitin-protein ligase RLIM

4.23E−03

2.46

8.11E−03

O60494

Cubilin

1.18E−03

27.19

1.29E−02

P01023

Alpha-2-macroglobulin

1.27E−03

2.50

1.37E−02

[39, 40]

Q02880

DNA topoisomerase 2-beta

2.98E−03

3.25

1.37E−02

Q8WWI1

LIM domain only protein 7

4.23E−03

3.33

2.25E−02

[76]

O75665

Oral-facial-digital syndrome 1 protein

1.86E−02

3.36

2.25E−02

[77]

P36957

Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial

4.61E−02

5.50

3.53E−02

[78]

O75445

Usherin

3.35E−03

9.25

5.52E−02

P05546

Heparin cofactor 2

3.36E−03

3.99

5.52E−02

[37, 79]

Q8IZU0

Protein FAM9B

3.36E−03

4.14

5.52E−02

A0AUZ9

KAT8 regulatory NSL complex subunit 1-like protein

1.53E−02

2.11

5.52E−02

Q92766

Ras-responsive element-binding protein 1

3.88E−02

3.35

6.73E−02

Q5TEZ5

Uncharacterized protein C6orf163

1.25E−02

2.28

8.28E−02

P54317

Pancreatic lipase-related protein 2

4.51E−03

Only in controls

9.96E−02

Q9H6S0

Probable ATP-dependent RNA helicase YTHDC2

4.60E−03

2.31

1.21E−01

P01266

Thyroglobulin

9.90E−03

0.46

1.21E−01

P08185

Corticosteroid-binding globulin

3.26E−02

3.35

1.21E−01

[80]

Q5T200

Zinc finger CCCH domain-containing protein 13

4.18E−03

5.71

1.35E−01

P18428

Lipopolysaccharide-binding protein

7.55E−04

0.43

1.71E−01

[81]

P98164

Low-density lipoprotein receptor-related protein 2

1.25E−02

3.92

1.71E−01

[58]  

Q5T011

Protein SZT2

1.86E−02

0.37

1.71E−01

P04114

Apolipoprotein B-100

3.26E−02

2.16

1.71E−01

[41, 42, 46]

Q9NS86

LanC-like protein 2

4.64E−02

2.76

1.71E−01

Q9H7L9

Sin3 histone deacetylase corepressor complex component SDS3

1.84E−02

2.50

2.00E−01

O60884

DnaJ homolog subfamily A member 2

2.67E−03

2.21

2.31E−01

Q5T481

RNA-binding protein 20

9.84E−04

4.61

2.35E−01

[47, 82]  

Q5VZL5

Zinc finger MYM-type protein 4

5.30E−03

0.38

2.62E−01

O15553

Pyrin

1.72E−03

2.65

2.74E−01

[49,50,51, 83]

Q96PV0

Ras/Rap GTPase-activating protein SynGAP

7.33E−03

0.49

3.11E−01

Q8N436

Inactive carboxypeptidase-like protein X2

1.84E−02

0.37

3.11E−01

Q14767

Latent-transforming growth factor beta-binding protein 2

7.58E−04

0.43

3.15E−01

[84]

Q8IWB6

Inactive serine/threonine–protein kinase TEX14

3.84E−02

2.43

3.60E−01

Q5T9S5

Coiled-coil domain-containing protein 18

2.01E−02

0.25

3.89E−01

Q8N163

Cell cycle and apoptosis regulator protein 2

3.51E−02

0.17

3.89E−01

Q9GZU1

Mucolipin-1

1.46E−02

0.48

4.10E−01

O43301

Heat shock 70 kDa protein 12A

1.68E−02

3.91

4.11E−01

[85]

A6NES4

Maestro heat-like repeat-containing protein family member 2A

7.55E−04

0.24

6.48E−01