Fig. 2
Immunohistochemical analysis for GLUT-1 expression in resected intrahepatic cholangiocarcinoma specimens and 18F-FDG-PET/CT scans. a A tumor with wild-type KRAS showed negative staining (score 0) for GLUT-1, and 18F-FDG-PET/CT scans showed modest accumulation of 18F-FDG in the tumor (MTV, 3.6; TLG, 31.9). b A tumor with mutated KRAS showed moderate membranous staining (score 3) for GLUT-1, and 18F-FDG-PET/CT scans showed intense accumulation of 18F-FDG in the tumor (MTV, 76; TLG 213). The scale bar represents 100 μm. GLUT-1 glucose transporter-1, 18F-FDG-PET 18F-fluorodeoxyglucose positron emission tomography, MTV metabolic tumor volume, TLG total lesion glycolysis