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Table 4 Percentage of participants experiencing criteria-defined, non-mandatory symptoms for three levels of ME/CFS severity (increasing order of occurrence from healthy/mild to severe cohorts)

From: Weighting of orthostatic intolerance time measurements with standing difficulty score stratifies ME/CFS symptom severity and analyte detection

Criterion Healthy/mild % (n = 24) Moderate % (n = 21) Severe % (n = 14) p value (χ2 test)
Headaches monthly 0 14 21 0.0801
Migraine 0 14 7 0.1636
Headaches daily 8 43 28 0.0282*
Sensitive to smell 8 52 57 0.0014*
Sensitive to touch 13 23 36 0.2425
Headaches weekly 13 29 36 0.217
  1. All mild to severe cases reported > 6-months fatigue and post exertional malaise
  2. * Statistical significance at p < 0.05