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Fig. 1 | Journal of Translational Medicine

Fig. 1

From: Cisplatin based therapy: the role of the mitogen activated protein kinase signaling pathway

Fig. 1

Various strategies to overcome cisplatin resistance. Delivery of cisplatin to target DNA can be improved by administering cisplatin in liposomes or polymers, and by inhibiting cisplatin inactivating species like glutathione and metallothionein. Cisplatin resistance can also be controlled by using antisense oligodeoxynucleotides (ODN) targeting responsible oncogenes for cisplatin resistance or by enhancement of cisplatin activity by combining with other drugs

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