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Table 1 Baseline characteristics for patients with FSGS according to tertiles of urinary miR-196a

From: Urinary miR-196a predicts disease progression in patients with chronic kidney disease

Characteristic Total (n = 231) Patients according to tertiles of urinary miR-196a p value
Tertile 1 (n = 78) Tertile 2 (n = 77) Tertile 3 (n = 76)
Age (years) 26.0 (20.0, 41.0) 24.5 (19.0, 39.0) 28.0 (21.0, 42.0) 25.5 (20.0, 42.8) 0.554
Male, % (n) 68.4 (158) 67.9 (53) 66.2 (51) 71.1 (54) 0.810
Hypertension, % (n) 17.3 (40) 10.3 (8) 28.6 (22) 13.2 (10) 0.005
eGFR (mL/min/1.73 m2) 104.07 (62.61, 123.73) 111.57 (82.77, 130.05) 99.75 (57.85, 123.26) 86.23 (55.43, 115.24) 0.005
Proteinuria (g/24 h) 6.93 (3.97, 9.94) 5.49 (2.87, 8.14) 7.80 (4.29, 10.42) 7.15 (5.07, 10.85) 0.003
Albumin (g/L) 21.20 (18.70, 26.90) 22.55 (19.18, 30.03) 20.30 (18.08, 27.20) 20.65 (18.20, 23.98) 0.064
Serum creatinine (mg/dL) 0.91 (0.69, 1.42) 0.82 (0.64, 1.01) 0.95 (0.67, 1.54) 1.03 (0.75, 1.66) 0.005
Total cholesterol (mmol/L) 9.52 (7.48, 12.28) 8.74 (6.86, 11.95) 9.52 (7.67, 12.25) 10.04 (7.94, 13.04) 0.056
Triglyceride (mmol/L) 2.81 (2.02, 3.75) 2.47 (1.77, 3.41) 2.96 (2.25, 4.00) 3.00 (2.17, 4.05) 0.013
Global glomerulosclerosis (%) 0.00 (0.00, 6.06) 0.00 (0.00, 6.67) 0.00 (0.00, 5.44) 0.00 (0.00, 4.89) 0.304
Segmental glomerulosclerosis (%) 12.50 (5.88, 22.22) 9.88 (5.26, 19.78) 12.50 (5.88, 23.30) 14.29 (6.32, 25.00) 0.436
Interstitial fibrosis (%) 4.45 (0.00, 13.39) 2.98 (0.00, 9.86) 4.45 (0.00, 8.95) 7.12 (2.31, 21.21) 0.004
Tubular atrophy (%) 1.01 (0.00, 7.01) 0.76 (0.00, 6.16) 0.82 (0.00, 5.00) 1.70 (0.00, 20.25) 0.038
Patients with nephrotic syndrome, % (n) 80.1 (185) 66.7 (52) 84.4 (65) 89.5 (68) 0.001
Patients progression to ESRD, % (n) 20.3 (47) 7.7 (6) 15.6 (12) 38.2 (29) < 0.001
  1. Data are shown as median (25th, 75th percentiles) for continuous variables and percent (n) for categorical variables
  2. Conversion factors: serum creatinine in mg/dL to μmol/L, ×88.4
  3. FSGS focal segmental glomerulosclerosis, eGFR estimated glomerular filtration rate