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Table 1 Baseline characteristics for patients with FSGS according to tertiles of urinary miR-196a

From: Urinary miR-196a predicts disease progression in patients with chronic kidney disease

Characteristic

Total (n = 231)

Patients according to tertiles of urinary miR-196a

p value

Tertile 1 (n = 78)

Tertile 2 (n = 77)

Tertile 3 (n = 76)

Age (years)

26.0 (20.0, 41.0)

24.5 (19.0, 39.0)

28.0 (21.0, 42.0)

25.5 (20.0, 42.8)

0.554

Male, % (n)

68.4 (158)

67.9 (53)

66.2 (51)

71.1 (54)

0.810

Hypertension, % (n)

17.3 (40)

10.3 (8)

28.6 (22)

13.2 (10)

0.005

eGFR (mL/min/1.73 m2)

104.07 (62.61, 123.73)

111.57 (82.77, 130.05)

99.75 (57.85, 123.26)

86.23 (55.43, 115.24)

0.005

Proteinuria (g/24 h)

6.93 (3.97, 9.94)

5.49 (2.87, 8.14)

7.80 (4.29, 10.42)

7.15 (5.07, 10.85)

0.003

Albumin (g/L)

21.20 (18.70, 26.90)

22.55 (19.18, 30.03)

20.30 (18.08, 27.20)

20.65 (18.20, 23.98)

0.064

Serum creatinine (mg/dL)

0.91 (0.69, 1.42)

0.82 (0.64, 1.01)

0.95 (0.67, 1.54)

1.03 (0.75, 1.66)

0.005

Total cholesterol (mmol/L)

9.52 (7.48, 12.28)

8.74 (6.86, 11.95)

9.52 (7.67, 12.25)

10.04 (7.94, 13.04)

0.056

Triglyceride (mmol/L)

2.81 (2.02, 3.75)

2.47 (1.77, 3.41)

2.96 (2.25, 4.00)

3.00 (2.17, 4.05)

0.013

Global glomerulosclerosis (%)

0.00 (0.00, 6.06)

0.00 (0.00, 6.67)

0.00 (0.00, 5.44)

0.00 (0.00, 4.89)

0.304

Segmental glomerulosclerosis (%)

12.50 (5.88, 22.22)

9.88 (5.26, 19.78)

12.50 (5.88, 23.30)

14.29 (6.32, 25.00)

0.436

Interstitial fibrosis (%)

4.45 (0.00, 13.39)

2.98 (0.00, 9.86)

4.45 (0.00, 8.95)

7.12 (2.31, 21.21)

0.004

Tubular atrophy (%)

1.01 (0.00, 7.01)

0.76 (0.00, 6.16)

0.82 (0.00, 5.00)

1.70 (0.00, 20.25)

0.038

Patients with nephrotic syndrome, % (n)

80.1 (185)

66.7 (52)

84.4 (65)

89.5 (68)

0.001

Patients progression to ESRD, % (n)

20.3 (47)

7.7 (6)

15.6 (12)

38.2 (29)

< 0.001

  1. Data are shown as median (25th, 75th percentiles) for continuous variables and percent (n) for categorical variables
  2. Conversion factors: serum creatinine in mg/dL to μmol/L, ×88.4
  3. FSGS focal segmental glomerulosclerosis, eGFR estimated glomerular filtration rate