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Table 1 Patient characteristics and biomarkers

From: Sex and interleukin-6 are prognostic factors for autoimmune toxicity following treatment with anti-CTLA4 blockade

Patients characteristics

Median or N (range or %)

Sex

 Male

86 (61.4)

 Female

54 (38.6)

Age

63.0 (27.0–85.0)

Number of previous treatments

1 (0–4)

Follow-up (months)

9.8 (2.4–53.6)

Biomarker (normal range)

Median (range)

White blood cells (4.40–11.00 × 106/L)

6.2 (2.3–17.5)

Eosinophils (0–0.50 × 106/L)

0.08 (0.01–0.89)

Neutrophils (1.80–7.8 × 106/L)

4.0 (1.1–16.2)

Lymphocytes (1.10–4.80 × 106/L)

1.3 (0.7–2.5)

 CD3+ (7.0–27.0%)

71.0 (42.0–92.0)

 CD4+ (32–52%)

39.0 (17.0–73.0)

 CD8+ (16–33%)

23.0 (5.3–79.0)

 NK (7.0–27.0%)

18.0 (5.6–35.6)

 CD3/CD16/CD56+ (1–11%)

3.0 (1.0–13.0)

LDH (< 1, × UNL)

0.9 (0.4–11.56)

CRP (0–6 mg/L)

6.7 (2.9–214.0)

β2-microglobulin (1.09–2.53 ng/L)

2.3 (1.2–7.2)

IL6 (0–5.9 ng/L)

3.5 (2.0–658.0)

IL2 (0–2 ng/L)

7 (2–28.3)

S-100 (0.00–0.15 μg/L)

0.6 (0.03–97.0)

VEGF (62–707 ng/L)

431.5 (3.4–2100.0)

  1. The table describes the features of the patients included in the study. Of note, most of the biomarkers lied within the normal ranges with the exception of CD3 positive lymphocytes, IL2 and S-100 levels, that were superior to the value of the average healthy population