Fig. 2
From: The physiological role of Motin family and its dysregulation in tumorigenesis
Schematic models of AMOTs interplayed with Hippo-YAP1 cascade. In this model, AMOTs mainly inhibits YAP1 by regulating its localization and promoting Hippo-mediated phosphorylation of YAP1. a AMOTs and YAP1 were co-translocated to the nuclear to promote the transcription of YAP1-target genes. b AMOTs bind with Merlin at the tight junctions and phosphorylate MST1/2 and LATS1/2. Phosphorylated LATS1/2 inactives YAP1 through phosphorylation, resulting in its degradation. c AMOTs physically interact with YAP1 to maintain it cytoplasmic retention. d Actin and YAP1 compete for binding with AMOTs in the tight junctions. TJ tight junction