Fig. 3

Epithelial proteomic networks for TRIM28 high (a) and low (b) ratio cases. Both, TRIM28 high (a) and TRIM28 low ratio (b) epithelial tumor tissue proteomic networks consist of three main sub-networks (green, pink and light green). Dominant nodes in the high ratio networks represent pro-survival pathways. Prominent nodes in the low ratio proteomic networks represent pro-apoptotic pathways. Nodes represent proteins quantified by RPPA; the bigger the node, the more significant correlations relative to that molecule. Each line connecting 2 nodes represents a significant correlation between the nodes; the thicker the line, the higher the Spearman ρ correlation. Proteins are grouped on the basis of Spearman ρ values and the number of connections among a group of nodes; strongly correlated nodes are represented close to each other and with the same color