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Fig. 2 | Journal of Translational Medicine

Fig. 2

From: Stromal TRIM28-associated signaling pathway modulation within the colorectal cancer microenvironment

Fig. 2

Stromal proteomic networks for TRIM28 high (a) and low (b) ratio cases. Both, TRIM28 high (a) and TRIM28 low ratio (b) stromal tissue proteomic networks consist of three main sub-networks (green, pink and light green). Dominant nodes in the high ratio sub-networks are proteins linked to tumor progression and nodes prominent in the low ratio sub-networks are proteins linked to apoptosis. Nodes represent proteins quantified by RPPA; the bigger the node, the more significant correlations relative to that protein. Each line connecting 2 nodes represents a significant correlation between the nodes; the thicker the line, the higher the Spearman ρ correlation. Proteins are grouped on the basis of Spearman ρ values and the number of connections among a group of nodes; strongly correlated nodes are represented close to each other and with the same color

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