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Table 6 Univariate and multivariate Cox regression analysis of SNPs associated with AML overall survival (OS)

From: Association of genetic polymorphisms in genes involved in Ara-C and dNTP metabolism pathway with chemosensitivity and prognosis of adult acute myeloid leukemia (AML)

Genotype

n

Mean ± SE (day)

Median (range) (day)

HR (95% CI)

P

HR (95% CI)a

P a

NME1 rs3760468

 AA

135

1326 ± 209

1534 (947–2121)

1.00 (reference)

 

1.00 (reference)

 

 AT

160

1232 ± 218

768 (388–1148)

1.238 (0.890–1.724)

0.205

1.455 (1.015–2.087)

0.041

 TT

47

801 ± 231

513 (398–638)

1.652 (1.067–2.557)

0.024

1.702 (1.072–2.704)

0.024

 AT+TT

207

1159 ± 185

663 (442–884)

1.328 (0.973–1.812)

0.073

1.518 (1.082–2.129)

0.016

NME2 rs3744660

 GG

230

1283 ± 168

1159 (615–1703)

1.00 (reference)

 

1.00 (reference)

 

 AG

98

1175 ± 252

817 (410–1224)

1.283 (0.924–1.780)

0.137

1.181 (0.831–1.679)

0.353

 AA

15

442 ± 149

359 (167–551)

2.214 (1.154–4.247)

0.017

2.284 (1.145–4.559)

0.019

 GG+AG

328

1261 ± 143

988 (682–1294)

1.00 (reference)

 

1.00 (reference)

 

 AA

15

442 ± 149

359 (167–511)

2.054 (1.080–3.905)

0.025

2.172 (1.098–4.294)

0.026

RRM1 rs183484

 GG

109

940 ± 167

672 (454–890)

1.00 (reference)

 

1.00 (reference)

 

 GT

194

1506 ± 202

1749 (799–2699)

0.692 (0.496–0.964)

0.030

0.599 (0.413–0.868)

0.007

 TT

46

993 ± 305

414 (162–666)

1.112 (0.717–1.726)

0.635

1.063 (0.665–1.698)

0.799

RRM2 rs1130609

 TT

148

1243 \± 201

1025 (426–1624)

1.00 (reference)

 

1.00 (reference)

 

 GT

161

1380 ± 209

843 (520–1166)

0.988 (0.719–1.357)

0.941

1.025 (0.746–1.408)

0.881

 GG

36

753 ± 248

473 (137–809)

1.506 (0.917–2.475)

0.106

1.489 (0.906–2.448)

0.116

 TT+GT

309

1297 ± 153

935 (645–1225)

1.00 (reference)

 

1.00 (reference)

 

 GG

36

753 ± 248

473 (137–809)

1.516 (0.948–2.422)

0.080

1.471 (0.920–2.352)

0.107

  1. aAdjusted for risk stratification, WBC count, allo-SCT, age, and serum LDH level