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Table 6 Univariate and multivariate Cox regression analysis of SNPs associated with AML overall survival (OS)

From: Association of genetic polymorphisms in genes involved in Ara-C and dNTP metabolism pathway with chemosensitivity and prognosis of adult acute myeloid leukemia (AML)

Genotype n Mean ± SE (day) Median (range) (day) HR (95% CI) P HR (95% CI)a P a
NME1 rs3760468
 AA 135 1326 ± 209 1534 (947–2121) 1.00 (reference)   1.00 (reference)  
 AT 160 1232 ± 218 768 (388–1148) 1.238 (0.890–1.724) 0.205 1.455 (1.015–2.087) 0.041
 TT 47 801 ± 231 513 (398–638) 1.652 (1.067–2.557) 0.024 1.702 (1.072–2.704) 0.024
 AT+TT 207 1159 ± 185 663 (442–884) 1.328 (0.973–1.812) 0.073 1.518 (1.082–2.129) 0.016
NME2 rs3744660
 GG 230 1283 ± 168 1159 (615–1703) 1.00 (reference)   1.00 (reference)  
 AG 98 1175 ± 252 817 (410–1224) 1.283 (0.924–1.780) 0.137 1.181 (0.831–1.679) 0.353
 AA 15 442 ± 149 359 (167–551) 2.214 (1.154–4.247) 0.017 2.284 (1.145–4.559) 0.019
 GG+AG 328 1261 ± 143 988 (682–1294) 1.00 (reference)   1.00 (reference)  
 AA 15 442 ± 149 359 (167–511) 2.054 (1.080–3.905) 0.025 2.172 (1.098–4.294) 0.026
RRM1 rs183484
 GG 109 940 ± 167 672 (454–890) 1.00 (reference)   1.00 (reference)  
 GT 194 1506 ± 202 1749 (799–2699) 0.692 (0.496–0.964) 0.030 0.599 (0.413–0.868) 0.007
 TT 46 993 ± 305 414 (162–666) 1.112 (0.717–1.726) 0.635 1.063 (0.665–1.698) 0.799
RRM2 rs1130609
 TT 148 1243 \± 201 1025 (426–1624) 1.00 (reference)   1.00 (reference)  
 GT 161 1380 ± 209 843 (520–1166) 0.988 (0.719–1.357) 0.941 1.025 (0.746–1.408) 0.881
 GG 36 753 ± 248 473 (137–809) 1.506 (0.917–2.475) 0.106 1.489 (0.906–2.448) 0.116
 TT+GT 309 1297 ± 153 935 (645–1225) 1.00 (reference)   1.00 (reference)  
 GG 36 753 ± 248 473 (137–809) 1.516 (0.948–2.422) 0.080 1.471 (0.920–2.352) 0.107
  1. aAdjusted for risk stratification, WBC count, allo-SCT, age, and serum LDH level