Genotype | n | Mean ± SE (day) | Median (range, day) | HR (95% CI) | P | HR (95% CI)a | P a |
---|---|---|---|---|---|---|---|
NME1 rs3760468 | |||||||
 AA | 113 | 1058 ± 202 | 751 (294–1208) | 1.00 (reference) |  | 1.00 (reference) |  |
 AT | 121 | 1163 ± 212 | 894 (378–1410) | 0.946 (0.657–1.362) | 0.764 | 1.027 (0.709–1.488) | 0.887 |
 TT | 39 | 655 ± 207 | 357 (285–429) | 1.703 (1.070–2.709) | 0.025 | 1.744 (1.085–2.801) | 0.022 |
 AA+AT | 234 | 1110 ± 149 | 761 (379–1143) | 1.00 (reference) |  | 1.00 (reference) |  |
 TT | 39 | 655 ± 207 | 357 (285–429) | 1.752 (1.142–2.686) | 0.009 | 1.854 (1.197–2.871) | 0.006 |
NME1 rs2302254 | |||||||
 CC | 169 | 941 ± 129 | 724 (4484–964) | 1.00 (reference) |  | 1.00 (reference) |  |
 CT | 87 | 1324 ± 266 | 1282 (516–2048) | 0.770 (0.526–1.126) | 0.177 | 0.728 (0.494–1.071) | 0.107 |
 TT | 22 | 581 ± 253 | 373 (286–460) | 1.756 (1.014–3.042) | 0.044 | 1.688 (0.973–2.928) | 0.062 |
 CC+CT | 256 | 1111 ± 156 | 760 (398–1122) | 1.00 (reference) |  | 1.00 (reference) |  |
 TT | 22 | 581 ± 253 | 373 (286–460) | 1.912 (1.117–3.272) | 0.016 | 1.878 (1.096–3.217) | 0.022 |
NME2 rs3744660 | |||||||
 GG | 191 | 987 ± 124 | 751 (397–1105) | 1.00 (reference) |  | 1.00 (reference) |  |
 AG | 71 | 1239 ± 283 | 976 (186–1766) | 0.929 (0.627–1.377) | 0.714 | 0.958 (0.644–1.425) | 0.832 |
 AA | 12 | 382 ± 116 | 373 (95–651) | 2.087 (1.051–4.145) | 0.036 | 2.224 (1.114–4.444) | 0.024 |
 GG+AG | 262 | 1136 ± 157 | 760 (399–1121) | 1.00 (reference) |  | 1.00 (reference) |  |
 AA | 12 | 382 ± 116 | 373 (95–651) | 2.127 (1.078–4.194) | 0.026 | 2.250 (1.135–4.460) | 0.020 |
RRM2 rs1130609 | |||||||
 TT | 123 | 1126 ± 208 | 751 (368–1134) | 1.00 (reference) |  | 1.00 (reference) |  |
 GT | 125 | 1129 ± 216 | 724 (209–1239) | 1.561 (0.692–1.386) | 0.907 | 0.926 (0.651–1.317) | 0.668 |
 GG | 29 | 679 ± 272 | 371 (200–542) | 1.561 (0.900–2.707) | 0.113 | 1.437 (0.825–2.501) | 0.200 |
 TT+GT | 248 | 1127 ± 159 | 729 (381–1077) | 1.00 (reference) |  | 1.00 (reference) |  |
 GG | 29 | 679 ± 272 | 371 (200–542) | 1.577 (0.935–2.660) | 0.085 | 1.493 (0.882–2.528) | 0.136 |