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Table 5 Univariate and multivariate Cox regression analysis of SNPs associated with AML relapse-free survival (RFS)

From: Association of genetic polymorphisms in genes involved in Ara-C and dNTP metabolism pathway with chemosensitivity and prognosis of adult acute myeloid leukemia (AML)

Genotype

n

Mean ± SE (day)

Median (range, day)

HR (95% CI)

P

HR (95% CI)a

P a

NME1 rs3760468

 AA

113

1058 ± 202

751 (294–1208)

1.00 (reference)

 

1.00 (reference)

 

 AT

121

1163 ± 212

894 (378–1410)

0.946 (0.657–1.362)

0.764

1.027 (0.709–1.488)

0.887

 TT

39

655 ± 207

357 (285–429)

1.703 (1.070–2.709)

0.025

1.744 (1.085–2.801)

0.022

 AA+AT

234

1110 ± 149

761 (379–1143)

1.00 (reference)

 

1.00 (reference)

 

 TT

39

655 ± 207

357 (285–429)

1.752 (1.142–2.686)

0.009

1.854 (1.197–2.871)

0.006

NME1 rs2302254

 CC

169

941 ± 129

724 (4484–964)

1.00 (reference)

 

1.00 (reference)

 

 CT

87

1324 ± 266

1282 (516–2048)

0.770 (0.526–1.126)

0.177

0.728 (0.494–1.071)

0.107

 TT

22

581 ± 253

373 (286–460)

1.756 (1.014–3.042)

0.044

1.688 (0.973–2.928)

0.062

 CC+CT

256

1111 ± 156

760 (398–1122)

1.00 (reference)

 

1.00 (reference)

 

 TT

22

581 ± 253

373 (286–460)

1.912 (1.117–3.272)

0.016

1.878 (1.096–3.217)

0.022

NME2 rs3744660

 GG

191

987 ± 124

751 (397–1105)

1.00 (reference)

 

1.00 (reference)

 

 AG

71

1239 ± 283

976 (186–1766)

0.929 (0.627–1.377)

0.714

0.958 (0.644–1.425)

0.832

 AA

12

382 ± 116

373 (95–651)

2.087 (1.051–4.145)

0.036

2.224 (1.114–4.444)

0.024

 GG+AG

262

1136 ± 157

760 (399–1121)

1.00 (reference)

 

1.00 (reference)

 

 AA

12

382 ± 116

373 (95–651)

2.127 (1.078–4.194)

0.026

2.250 (1.135–4.460)

0.020

RRM2 rs1130609

 TT

123

1126 ± 208

751 (368–1134)

1.00 (reference)

 

1.00 (reference)

 

 GT

125

1129 ± 216

724 (209–1239)

1.561 (0.692–1.386)

0.907

0.926 (0.651–1.317)

0.668

 GG

29

679 ± 272

371 (200–542)

1.561 (0.900–2.707)

0.113

1.437 (0.825–2.501)

0.200

 TT+GT

248

1127 ± 159

729 (381–1077)

1.00 (reference)

 

1.00 (reference)

 

 GG

29

679 ± 272

371 (200–542)

1.577 (0.935–2.660)

0.085

1.493 (0.882–2.528)

0.136

  1. aAdjusted for risk stratification, WBC count, and allo-SCT