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Table 3 Comparison of CR rate among genotypes after 2 courses of Ara-C based chemotherapy

From: Association of genetic polymorphisms in genes involved in Ara-C and dNTP metabolism pathway with chemosensitivity and prognosis of adult acute myeloid leukemia (AML)

Genotype

Total (n)

CR, n (%)

Non-CR, n (%)

P

OR (95% CI)

P a

OR (95% CI)a

CMPK1 rs7543016

 CC

93

57 (61.3%)

36 (38.7%)

 

1.00 (reference)

 

1.00 (reference)

 GC

167

106 (63.5%)

61 (36.5%)

0.727

0.911 (0.540–1.537)

0.921

0.970 (0.531–1.772)

 GG

30

23 (76.7%)

7 (23.3%)

0.125

0.482 (0.188–1.238)

0.076

0.365 (0.120–1.111)

NME1 rs3760468

 AA

115

77 (67.0%)

38 (33.0%)

 

1.00 (reference)

 

1.00 (reference)

 AT

154

96 (62.3%)

58 (37.7%)

0.434

1.224 (0.737–2.033)

0.256

1.420 (0.775–2.597)

 TT

44

26 (59.1%)

18 (40.9%)

0.353

1.403 (0.686–2.869)

0.465

1.359 (0.597–3.096)

NME1 rs2302254

 CC

186

123 (66.1%)

63 (33.9%)

 

1.00 (reference)

 

1.00 (reference)

 CT

114

65 (57.0%)

49 (43.0%)

0.114

1.473 (0.912–2.375)

0.288

1.355 (0.775–2.370)

 TT

19

13 (68.4%)

6 (31.6%)

0.840

0.901 (0.327–2.481)

0.534

0.688 (0.212–2.232)

NME2 rs3744660

 GG

213

146 (68.5%)

67 (31.5%)

 

1.00 (reference)

 

1.00 (reference)

 AG

89

48 (53.9%)

41 (46.1%)

0.016

1.861 (1.121–3.091)

0.024

1.953 (1.092–3.484)

 AA

14

8 (57.1%)

6 (42.9%)

0.376

1.634 (0.545–4.897)

0.770

1.299 (0.361–4.673)

 AA+AG

103

56 (54.4%)

47 (45.6%)

0.014

1.829 (1.127–2.967)

0.030

1.852 (1.062–3.236)

SAMHD1 rs6102991

 AA

88

49 (55.7%)

39 (44.3%)

 

1.00 (reference)

 

1.00 (reference)

 GA

161

107 (66.5%)

54 (33.5%)

0.093

0.634 (0.372–1.080)

0.183

0.669 (0.370–1.209)

 GG

62

43 (69.4%)

19 (30.6%)

0.090

0.555 (0.280–1.101)

0.063

0.483 (0.224–1.038)

 AG+GG

223

150 (67.3%)

73 (32.7%)

0.055

0.611 (0.369–1.013)

0.086

0.611 (0.349–1.071)

SAMHD1 rs28372906

 TT

284

180 (63.4%)

104 (36.6%)

 

1.00 (reference)

 

1.00 (reference)

 CT

32

21 (65.6%)

11 (34.4%)

0.802

0.907 (0.420–1.955)

0.878

0.935 (0.394–2.217)

 CC

4

3 (75.0%)

1 (25.0%)

0.632

0.577 (0.059–5.618)

0.953

0.933 (0.091–9.524)

SAMHD1 rs6029941

 GG

88

50 (56.8%)

38 (43.2%)

 

1.00 (reference)

 

1.00 (reference)

 GA

161

107 (66.5%)

54 (33.5%)

0.132

0.664 (0.389–1.132)

0.339

0.739 (0.398–1.374)

 AA

65

42 (64.6%)

23 (35.4%)

0.330

0.721 (0.372–1.395)

0.370

0.706 (0.330–1.512)

E2F1 rs3213180

 GG

149

95 (63.8%)

54 (36.2%)

 

1.00 (reference)

 

1.00 (reference)

 GC

141

90 (63.8%)

51 (36.2%)

0.990

0.997 (0.617–1.610)

0.915

0.970 (0.552–1.704)

 CC

29

16 (55.2%)

13 (44.8%)

0.383

1.429 (0.639–3.195)

0.429

1.449 (0.578–3.636)

E2F1 rs3213150

 CC

111

67 (60.4%)

44 (39.6%)

 

1.00 (reference)

 

1.00 (reference)

 CT

159

110 (69.2%)

49 (30.8%)

0.133

0.678 (0.408–1.127)

0.105

0.616 (0.343–1.106)

 TT

46

23 (50.0%)

23 (50.0%)

0.232

1.523 (0.762–3.042)

0.128

1.835 (0.839–4.016)

 CC+CT

270

177 (65.6%)

93 (34.4%)

 

1.00 (reference)

 

1.00 (reference)

 TT

46

23 (50.0%)

23 (50.0%)

0.043

1.903 (1.014–3.574)

0.033

2.208 (1.065–4.567)

RRM1 rs183484

 GG

100

62 (62.0%)

38 (38.0%)

 

1.00 (reference)

 

1.00 (reference)

 GT

177

118 (66.7%)

59 (33.3%)

0.434

0.816 (0.490–1.359)

0.112

0.617 (0.340–1.119)

 TT

42

22 (52.4%)

20 (47.6%)

0.287

1.483 (0.716–3.071)

0.263

1.616 (0.697–3.731)

RRM1 rs2412344

 TT

89

56 (62.9%)

33 (37.1%)

 

1.00 (reference)

 

1.00 (reference)

 CT

183

119 (65.0%)

64 (35.0%)

0.734

0.913 (0.539–1.545)

0.510

0.817 (0.449–1.488)

 CC

48

28 (58.3%)

20 (41.7%)

0.599

1.212 (0.592–2.483)

0.967

1.018 (0.429–2.415)

RRM2 rs1130609

 TT

131

84 (64.1%)

47 (35.9%)

 

1.00 (reference)

 

1.00 (reference)

 GT

149

100 (67.1%)

49 (32.9%)

0.599

0.876 (0.534–1.436)

0.920

0.972 (0.557–1.697)

 GG

34

15 (44.1%)

19 (55.9%)

0.034

2.264 (1.053–4.867)

0.069

2.347 (0.935–5.882)

 TT+GT

280

184 (65.7%)

96 (34.3%)

 

1.00 (reference)

 

1.00 (reference)

 GG

34

15 (44.1%)

19 (55.9%)

0.014

2.428 (1.181–4.990)

0.044

2.398 (1.025–5.618)

  1. aAdjusted by age, risk stratification, WBC count, and serum LDH level